Proliferation dynamics of acute myeloid leukaemia and haematopoietic progenitors competing for bone marrow space

Abstract

Leukaemia progressively invades bone marrow (BM), outcompeting healthy haematopoiesis by mechanisms that are not fully understood. Combining cell number measurements with a short-timescale dual pulse labelling method, we simultaneously determine the proliferation dynamics of primitive haematopoietic compartments and acute myeloid leukaemia (AML). We observe… (More)
DOI: 10.1038/s41467-017-02376-5

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