Proliferation-dependent topoisomerase II content as a determinant of antineoplastic drug action in human, mouse, and Chinese hamster ovary cells.

@article{Sullivan1987ProliferationdependentTI,
  title={Proliferation-dependent topoisomerase II content as a determinant of antineoplastic drug action in human, mouse, and Chinese hamster ovary cells.},
  author={Daniel Sullivan and Michael D. Latham and Warren E. Ross},
  journal={Cancer research},
  year={1987},
  volume={47 15},
  pages={3973-9}
}
We have shown previously that quiescent Chinese hamster ovary (CHO) cells are less sensitive than log phase CHO cells to the cytotoxic and DNA cleavage effects of etoposide, a drug which appears to act via DNA topoisomerase II. This loss of sensitivity was associated with a decrease in topoisomerase enzyme activity in nuclear extracts of the quiescent cells… CONTINUE READING