Proliferation-dependent changes in release of arachidonic acid from endothelial cells.

@article{Whatley1994ProliferationdependentCI,
  title={Proliferation-dependent changes in release of arachidonic acid from endothelial cells.},
  author={Ralph Whatley and Kaneo Satoh and Guy A. Zimmerman and Thomas M McIntyre and Stephen M. Prescott},
  journal={The Journal of clinical investigation},
  year={1994},
  volume={94 5},
  pages={1889-900}
}
Stimulation of endothelial cells resulted in release of arachidonic acid from phospholipids. The magnitude of this response decreased as the cells became confluent and the change coincided with a decrease in the percentage of cells in growth phases (G2+M); this was not a consequence of time in culture or a factor in the growth medium. Preconfluent cells released approximately 30% of arachidonic acid; confluent cells released only 6%. The decreasing release of arachidonic acid was demonstrated… CONTINUE READING