Proliferation-associated oxygen consumption and morphology of tumor cells in monolayer and spheroid culture.

@article{BredelGeiler1992ProliferationassociatedOC,
  title={Proliferation-associated oxygen consumption and morphology of tumor cells in monolayer and spheroid culture.},
  author={Anne Bredel-Gei\ssler and U Karbach and Stefan Walenta and Lutz Vollrath and Wolfgang F Mueller-Klieser},
  journal={Journal of cellular physiology},
  year={1992},
  volume={153 1},
  pages={44-52}
}
The oxygen consumption rate, proliferative activity, and morphology of EMT6/Ro mouse mammary sarcoma cells in monolayer and multicellular spheroid culture have been investigated in a comparative study. During the transition of monolayer cells from the exponential into the plateau growth phase, there is a distinct decrease in the cellular volume that is associated with a corresponding decrease in the proliferative and respiratory activity of the cells. The decline in cell volume is mainly due to… CONTINUE READING

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