Proliferation as a requirement for in vitro chondrogenesis of human mesenchymal stem cells.

@article{Dexheimer2012ProliferationAA,
  title={Proliferation as a requirement for in vitro chondrogenesis of human mesenchymal stem cells.},
  author={Verena Dexheimer and Sebastian Frank and Wiltrud Richter},
  journal={Stem cells and development},
  year={2012},
  volume={21 12},
  pages={2160-9}
}
During embryonic cartilage development, proliferation and differentiation are tightly linked with a transient cell cycle arrest observed during determination and before main extracellular matrix production. Aim of this study was to address whether these steps are imitated during in vitro differentiation of mesenchymal stem cells (MSCs) and are crucial for a proper chondrogenesis. Human MSCs were expanded in distinct media and subjected to pellet culture in chondrogenic medium. Cells were… CONTINUE READING
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