• Corpus ID: 28617473

Proliferation as a Major Risk Factor for Cancer : A Concept of Doubtful Validity 1

  title={Proliferation as a Major Risk Factor for Cancer : A Concept of Doubtful Validity 1},
  author={Emmanuel Farber},
An old idea, now being regenerated anew, focuses a major aspect of risk assessment for cancer on cell proliferation (1-11). It is now being proposed that the presence of cell proliferation by itself or the stim ulation of cell proliferation ¡na quiescent tissue or organ with low mitotic activity should be in and of themselves major concerns for cancer development in the particular tissue or organ. Also, the ability of an agent to induce cell proliferation in a target organ or tissue would be… 

Tables from this paper


Initiation of chemical carcinogenesis requires cell proliferation
A new approach to the sequential analysis of carcinogenesis in vivo is developed that delineates the first few steps in the process and is a quantitative assay for initiation of liver cancer, to investigate whether cell replication exerts its first effect on initiation or on some later step in the carcinogenic process.
The Role of Cell Proliferation in Multistage Carcinogenesis
  • B. Butterworth, T. Goldsworthy
  • Biology, Medicine
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1991
Knowledge of the relationship of induced cell proliferation to carcinogenic activity would be valuable in setting doses for cancer bioassays, classifying chemical carcinogens, and providing more realistic carcinogenic risk assessments.
Ideas in pathology. Pivotal role of increased cell proliferation in human carcinogenesis.
  • S. Cohen, D. Purtilo, L. Ellwein
  • Biology, Medicine
    Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • 1991
Cancer develops secondary to multiple genetic events. Each time a cell divides there is a rare chance that a genetic error related to the carcinogenic process will occur. Thus, environmental agents
Increased cell division as a cause of human cancer.
Under this increased cell division model, the pathogenesis of cancer may result from molecular genetic errors induced during the process of cell division and from altered growth control of malignant or premalignant cells.
There is evidence in a number of cases that cell replication alters neither the metabolism of the carcinogen, nor the nature, extent or persistence of the binding of the activated carcinogen to macromolecules.
Cell proliferation not associated with carcinogenesis in rodents and humans.
Evidence is presented that normal levels of cell turnover, or increasing the rate ofcell turnover at these different stages, do not necessarily lead to enhanced carcinogenesis, and that cell proliferation is not necessarily a tumor promoter or cocarcinogen.
Does chemically induced hepatocyte proliferation predict liver carcinogenesis?
  • R. Melnick
  • Biology, Medicine
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1992
The available literature leads to the conclusion that quantitative correspondences between cellular proliferation and carcinogenic responses have not been demonstrated and do not support the hypothesis that chemically induced cell proliferation is the primary mechanism by which nongenotoxic chemicals cause liver cancer.
Cell proliferation and the aetiology of hepatocellular carcinoma.
  • J. Berman
  • Biology, Medicine
    Journal of hepatology
  • 1988
Until a molecular mechanisms is demonstrated whereby HBV produces a defined cellular lesion that endows hepatocytes with a malignant phenotype, it should not be assumed that HBV is a direct cause of HCC.
Mechanisms, chemical carcinogenesis, and risk assessment: cell proliferation and cancer.
  • J. Huff
  • Medicine
    American journal of industrial medicine
  • 1995
This commentary offers a central and personal view of one such mechanism: cell proliferation and cancer.
Changes in epidermal cell proliferation in proliferative skin disease.
  • N. Wright
  • Medicine
    Current topics in pathology. Ergebnisse der Pathologie
  • 1985
There is good evidence that changes in cell proliferation accompany several well-recognised skin diseases, and the term ‘proliferative skin disease’ is now well-ingrained in the dermatological literature, but as yet the clinical impact of studies in epidermal cell proliferation has been muted.