Proliferation and tumorigenesis of a murine sarcoma cell line in the absence of DICER1.

@article{Ravi2012ProliferationAT,
  title={Proliferation and tumorigenesis of a murine sarcoma cell line in the absence of DICER1.},
  author={Arvind Ravi and Allan M. Gurtan and Manmohan Kumar and Arjun J. Bhutkar and Christine Wan Yee. Chin and Victoria Lu and Jacqueline A Lees and Tyler Jacks and Phillip A. Sharp},
  journal={Cancer cell},
  year={2012},
  volume={21 6},
  pages={
          848-55
        }
}
MicroRNAs are a class of short ~22 nucleotide RNAs predicted to regulate nearly half of all protein coding genes, including many involved in basal cellular processes and organismal development. Although a global reduction in miRNAs is commonly observed in various human tumors, complete loss has not been documented, suggesting an essential function for miRNAs in tumorigenesis. Here we present the finding that transformed or immortalized Dicer1 null somatic cells can be isolated readily in vitro… CONTINUE READING
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