Proliferation and motility responses of primary and recurrent gliomas related to changes in epidermal growth factor receptor expression

@article{Berens1996ProliferationAM,
  title={Proliferation and motility responses of primary and recurrent gliomas related to changes in epidermal growth factor receptor expression},
  author={Michael E. Berens and Monique D. Rief and Joan Rankin Shapiro and Dorothy Haskett and Alf Giese and Anna Joy and Stephen W. Coons},
  journal={Journal of Neuro-Oncology},
  year={1996},
  volume={27},
  pages={11-22}
}
Astrocytic neoplasms show a high incidence of elevated or mutated epidermal growth factor receptor (EGFR) expression. Although proliferative effects from EGFR activation are well described, the role that changes in this receptor play in glioma growth and migration remain poorly addressed. This report characterizes changes in the levels of EGFR expression in three glial tumors at initial presentation (resection) and at the time of recurrence. By quantitative flow cytometry the mean level of EGFR… CONTINUE READING