Proliferation and glycosaminoglycans secretion in fibroblasts from psoriatic skin: differential responses to retinoids

  title={Proliferation and glycosaminoglycans secretion in fibroblasts from psoriatic skin: differential responses to retinoids},
  author={G. C. Priestley},
  journal={British Journal of Dermatology},
  • G. Priestley
  • Published 1 November 1987
  • Biology, Medicine
  • British Journal of Dermatology
The effects of four retinoids, all‐trans‐retinoic acid (tretinoin), 13‐cis‐retinoic acid (isotretinoin), Ro 10–1670 (etrctin) and the arotinoid, Ro 15–0778, on fibroblast proliferation and glycosaminoglycans (GAG) secretion in vitro were studied. Fibroblast lines cultured from normal skin (HSF) were compared with those from lesional (PSA) and non‐lesional (PSB) psoriatic skin. In general, the retinoids inhibited proliferation; the action was cytostatic, in rank order tretinoin > isotretinoin… 

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  • G. Priestley
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  • M. Edward
  • Biology, Chemistry
    The British journal of dermatology
  • 1995
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Human Psoriatic Skin in Organ Culture: Comparison with Normal Skin Exposed to Exogenous Growth Factors and Effects of an Antibody to the EGF Receptor

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Acitretin : A Review of its Pharmacology and Therapeutic Use.

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Ro 10-9359 Retinoid Inhibits Both in vitro Epidermal Cell Proliferation and Differentiation

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Effect of retinyl acetate on sulfated glycosaminoglycan biosynthesis in dermal and epidermal cells in vitro.

The effects of retinyl acetate on the biosynthesis of sulfated glycosaminoglycans in dermal and epidermal cells isolated from newborn mice was investigated and there was no apparent change in the glycosaminationoglycan profile, with heparin and/or heparan sulfate being the major sulfated glucose profile.

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Density-dependent regulation of skin-fibroblast glycosaminoglycans in vitro: Control by a secreted factor

SummaryGlycosaminoglycans (GAG) secretion by human skin fibroblasts in monolayer culture was inversely proportional to cell density, the relationship applying both within and between cultures of

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Effects of retinoic acid on plasminogen activator and mitogenic responses of cultured mouse cells.

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