Proliferation and glycosaminoglycans secretion in fibroblasts from psoriatic skin: differential responses to retinoids

@article{Priestley1987ProliferationAG,
  title={Proliferation and glycosaminoglycans secretion in fibroblasts from psoriatic skin: differential responses to retinoids},
  author={G. C. Priestley},
  journal={British Journal of Dermatology},
  year={1987},
  volume={117}
}
  • G. Priestley
  • Published 1 November 1987
  • Biology, Medicine
  • British Journal of Dermatology
The effects of four retinoids, all‐trans‐retinoic acid (tretinoin), 13‐cis‐retinoic acid (isotretinoin), Ro 10–1670 (etrctin) and the arotinoid, Ro 15–0778, on fibroblast proliferation and glycosaminoglycans (GAG) secretion in vitro were studied. Fibroblast lines cultured from normal skin (HSF) were compared with those from lesional (PSA) and non‐lesional (PSB) psoriatic skin. In general, the retinoids inhibited proliferation; the action was cytostatic, in rank order tretinoin > isotretinoin… 

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