Proliferation and glycosaminoglycans secretion in fibroblasts from psoriatic skin: differential responses to retinoids

@article{PRIESTLEY1987ProliferationAG,
  title={Proliferation and glycosaminoglycans secretion in fibroblasts from psoriatic skin: differential responses to retinoids},
  author={G.C. PRIESTLEY},
  journal={British Journal of Dermatology},
  year={1987},
  volume={117}
}
  • G.C. PRIESTLEY
  • Published 1 November 1987
  • Biology, Medicine
  • British Journal of Dermatology
The effects of four retinoids, all‐trans‐retinoic acid (tretinoin), 13‐cis‐retinoic acid (isotretinoin), Ro 10–1670 (etrctin) and the arotinoid, Ro 15–0778, on fibroblast proliferation and glycosaminoglycans (GAG) secretion in vitro were studied. Fibroblast lines cultured from normal skin (HSF) were compared with those from lesional (PSA) and non‐lesional (PSB) psoriatic skin. In general, the retinoids inhibited proliferation; the action was cytostatic, in rank order tretinoin > isotretinoin… 
View on Wiley
ncbi.nlm.nih.gov
22 Citations
Background Citations
4
Results Citations
1

22 Citations

Glycosaminoglycans production by cultured skin fibroblasts from the Pasini and Cockayne-Touraine forms of dominant dystrophic epidermolysis bullosa.

  • G. Priestley
  • Biology, Medicine
    The Journal of investigative dermatology
  • 1991
Findings are consistent with current views of albopapuloid lesions as an unreliable clinical sign in epidermolysis bullosa and bring into question the validity of the Pasini entity.

In vivo prevention of corticosteroid-induced skin atrophy by tretinoin in the hairless mouse is accompanied by modulation of collagen, glycosaminoglycans, and fibronectin.

It is concluded that tretinoin has the ability to prevent the major steroid-induced biomechanical changes in hairless mouse dermal connective tissue that contribute to atrophy.

Retinol, at concentrations greater than the physiological limit, induces oxidative stress and apoptosis in human dermal fibroblasts

Vitamin E and coenzyme Q10 had a protective effect against oxidative stress generated by retinol, and in the case of vitamin E the expression of CRABP‐II mRNA was induced, providing a plausible explanation for its protective effect.

Retinoic acid potentiates interleukin-1- and fibroblast growth factor-induced human synovial fibroblast proliferation.

Effects of retinoids on glycosaminoglycan synthesis by human skin fibroblasts grown as monolayers and within contracted collagen lattices

  • M. Edward
  • Biology, Chemistry
    The British journal of dermatology
  • 1995
Q‐Sepharose ion‐exchange chromatography at pH 2–0 revealed that there was no change in the degree of polymer sulphation of either chondroitin sulphate or heparan sulphate isolated from collagen lattice cultures compared with monolayer cultures.

Anti-CD11a Ameliorates Disease in the Human Psoriatic Skin–SCID Mouse Transplant Model: Comparison of Antibody to CD11a with Cyclosporin A and Clobetasol Propionate

Data indicate that, in this model, therapies directed against pathophysiologic mechanisms that contribute to psoriasis can be distinguished from treatments that block epidermal hyperplasia occurring as a consequence of xenografting.

Human Psoriatic Skin in Organ Culture: Comparison with Normal Skin Exposed to Exogenous Growth Factors and Effects of an Antibody to the EGF Receptor

The data suggest that growth factors which act through the EGF receptor help to maintain the psoriatic phenotype in organ culture and suggest that organ culture may provide a useful tool with which to elucidate the pathophysiological mechanisms of altered keratinocyte proliferation and differentiation in psoriasis.

All-trans retinoic acid stimulates growth and extracellular matrix production in growth-inhibited cultured human skin fibroblasts.

The data indicate that all-trans retinoic acid can induce changes in dermal fibroblasts in vitro (i.e., increased proliferation and extracellular matrix production) that mimic the major changes seen in the dermis after topical treatment with this agent.

Acitretin : A Review of its Pharmacology and Therapeutic Use.

Acitretin has an established place in the treatment of keratinising disorders, although its use in women of child-bearing potential must be accompanied by effective contraceptive measures, with a further 2-year contraceptive period after therapy completion.

Acitretin. A review of its pharmacology and therapeutic use.

Acitretin (etretin), a second generation monoaromatic retinoid for use in the treatment of severe psoriasis and other dermatoses, is the major active metabolite of etretinate and possesses a similar…

References

SHOWING 1-10 OF 17 REFERENCES

Ro 10-9359 Retinoid Inhibits Both in vitro Epidermal Cell Proliferation and Differentiation

It is concluded that Ro 109359 can inhibit both the proliferation and fibrous protein synthesis (differentiation) of isolated epidermal cells in culture.

Effect of retinyl acetate on sulfated glycosaminoglycan biosynthesis in dermal and epidermal cells in vitro.

The effects of retinyl acetate on the biosynthesis of sulfated glycosaminoglycans in dermal and epidermal cells isolated from newborn mice was investigated and there was no apparent change in the glycosaminationoglycan profile, with heparin and/or heparan sulfate being the major sulfated glucose profile.

Cellular retinoic acid- but not cellular retinol-binding protein is elevated in psoriatic plaques.

The results suggest for the first time a link between the levels of CRABP and the responsiveness of a nonneoplastic hyperproliferative tissue to systemic administration of retinoids in the human.

Proliferative responses of fibroblasts from psoriatic and normal skin to clobetasol propionate.

A differential sensitivity to the drug was demonstrated: the fibroblasts from involved psoriatic skin were more stimulated than normal fibro Blasts at 0.1 microgram/ml and then more inhibited at 10 micrograms/ml.

On The Effects Induced by Aromatic Retinoid Ro 10-9359 on Explants of Skin from Psoriatic Patients

The recent introduction in therapeutical practice of retinoids derived from vitamin A has promoted a whole series of studies which have shown how retinoic acid and its analogs, besides regulating…

Connective tissue synthesis by cultured scleroderma fibroblasts. II. Incorporation of 3h-glucosamine and synthesis of glycosaminoglycans.

Fibroblasts from normal and scleroderma skin, grown tissue culture, were incubated with 3H-glucosamine for 24 hours and characterization of glycosaminoglycans showed that in both the medium and cells, hyaluronic acid was the major glyCosaminoglycan in normal andScleroderMA fibroblast.

Effect of vitamin A and its derivatives on collagen production and chemotactic response of fibroblasts

The chemotactic response of fibroblasts to fibroblast‐conditioned medium was markedly reduced in the presence of retinoids, and synthesis of non‐collagenous proteins and production of both type I and type III collagen were decreased.

Mitogenic Properties of Aromatic Retinoids: in vivo and in vitro Effects on Epidermal Cells

In vivo repeated application of RA leads to epidermal hyperplasia, which shows psoriasiform changes in the guinea pig ear, and in vitro the presence of RA in the culture medium increases the attachment ofEpidermal cells and causes rapid expansion and growth of the cell cultures.

Effects of retinoic acid on plasminogen activator and mitogenic responses of cultured mouse cells.

Under certain conditions, RA may have cell-activating properties, and caution should be exercised with regard to its suggested use as an antitumor agent.

Connective tissue synthesis by cultured scleroderma fibroblasts

Fibroblasts from normal and scleroderma skin, grown tissue culture, were incubated with 3H-glucosamine for 24 hours and characterization of glycosaminoglycans showed that in both the medium and cells, hyaluronic acid was the major glyCosaminoglycan in normal andScleroderMA fibroblast.