Proliferation and differentiation in the human breast during pregnancy.

  title={Proliferation and differentiation in the human breast during pregnancy.},
  author={Rami N Suzuki and Amanda J. Atherton and M J O'hare and A. R. Entwistle and Sunil R Lakhani and Catriona Clarke},
  journal={Differentiation; research in biological diversity},
  volume={66 2-3},
Using multiple immunofluorescence labelling on human breast tissues obtained and freshly frozen at the 12th, 15th, and 18th weeks of pregnancy, we have shown that markers of mammary functional differentiation, milk proteins (beta-casein and kappa-casein), are synthesised by actively cycling (Ki67 positive) as well as non-cycling (Ki67 negative) cells. These results demonstrate that functional differentiation/maturation does not coincide with loss of proliferative potential in human mammary… CONTINUE READING

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 16 extracted citations

Similar Papers

Loading similar papers…