Proliferating or interleukin 1-activated human vascular smooth muscle cells secrete copious interleukin 6.

@article{Loppnow1990ProliferatingOI,
  title={Proliferating or interleukin 1-activated human vascular smooth muscle cells secrete copious interleukin 6.},
  author={Harald Loppnow and P. Scott Libby},
  journal={The Journal of clinical investigation},
  year={1990},
  volume={85 3},
  pages={731-8}
}
The cells that make up blood vessel walls appear to participate actively in local immune and inflammatory responses, as well as in certain vascular diseases. We tested here whether smooth muscle cells (SMC) can produce the important inflammatory mediator IL6. Unstimulated SMC in vitro elaborated 5 X 10(3) pg recIL6/24h (i.e., biological activity equivalent to 5 X 10(3) pg recombinant IL6 (recIL6), as determined in B9-assay with a recIL6 standard). Several pathophysiologically relevant factors… CONTINUE READING
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Cytokines and endothelial cell biology

  • T. Hirano, K. Yasukawa, +13 authors T. Kishimoto
  • 1990

Regula - tion of major histocompatibility gene expression in cultured human vascular smooth muscle cells

  • R Ross
  • Arteriosclerosis
  • 1989

proliferation

  • F. R. Jirik, T. J. Podor, T. Hirano, T. Kishimoto
  • 1989

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