Proliferating cell nuclear antigen promotes DNA synthesis past template lesions by mammalian DNA polymerase delta.

@article{Mozzherin1997ProliferatingCN,
  title={Proliferating cell nuclear antigen promotes DNA synthesis past template lesions by mammalian DNA polymerase delta.},
  author={Dmitry Ju Mozzherin and Shinya Shibutani and Chek Kun Tan and Kathleen M. Downey and Paul Anthony Fisher},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 12},
  pages={6126-31}
}
Consistent with previous observations, proliferating cell nuclear antigen (PCNA) promotes DNA synthesis by calf thymus DNA polymerase delta (pol delta) past several chemically defined template lesions including model abasic sites, 8-oxo-deoxyguanosine (dG) and aminofluorene-dG (but not acetylaminofluorene-dG). This synthesis is potentially mutagenic. The model abasic site was studied most extensively. When all deoxyribonucleoside triphosphates and a template bearing a model abasic site were… CONTINUE READING

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Consistent with previous observations , proliferating cell nuclear antigen ( PCNA ) promotes DNA synthesis by calf thymus DNA polymerase delta ( pol delta ) past several chemically defined template lesions including model abasic sites , 8-oxo - deoxyguanosine ( dG ) and aminofluorene - dG ( but not acetylaminofluorene - dG ) .
DNA Polymerase IIIGene product plays role in biological processDNA Replication
Proliferating cell nuclear antigen promotes DNA synthesis past template lesions by mammalian DNA polymerase delta .
Consistent with previous observations , proliferating cell nuclear antigen ( PCNA ) promotes DNA synthesis by calf thymus DNA polymerase delta ( pol delta ) past several chemically defined template lesions including model abasic sites , 8-oxo - deoxyguanosine ( dG ) and aminofluorene - dG ( but not acetylaminofluorene - dG ) .
Consistent with previous observations , proliferating cell nuclear antigen ( PCNA ) promotes DNA synthesis by calf thymus DNA polymerase delta ( pol delta ) past several chemically defined template lesions including model abasic sites , 8-oxo - deoxyguanosine ( dG ) and aminofluorene - dG ( but not acetylaminofluorene - dG ) .
Consistent with previous observations , proliferating cell nuclear antigen ( PCNA ) promotes DNA synthesis by calf thymus DNA polymerase delta ( pol delta ) past several chemically defined template lesions including model abasic sites , 8-oxo - deoxyguanosine ( dG ) and aminofluorene - dG ( but not acetylaminofluorene - dG ) .
p21 , a specific inhibitor of PCNA - dependent DNA replication , inhibits PCNA - stimulated synthesis past model abasic template sites .
p21 , a specific inhibitor of PCNA - dependent DNA replication , inhibits PCNA - stimulated synthesis past model abasic template sites .
Proliferating Cell Nuclear AntigenGene product plays role in biological processDNA Replication
p21 , a specific inhibitor of PCNA - dependent DNA replication , inhibits PCNA - stimulated synthesis past model abasic template sites .
p21 , a specific inhibitor of PCNA - dependent DNA replication , inhibits PCNA - stimulated synthesis past model abasic template sites .
Consistent with previous observations , proliferating cell nuclear antigen ( PCNA ) promotes DNA synthesis by calf thymus DNA polymerase delta ( pol delta ) past several chemically defined template lesions including model abasic sites , 8-oxo - deoxyguanosine ( dG ) and aminofluorene - dG ( but not acetylaminofluorene - dG ) .
p21 , a specific inhibitor of PCNA - dependent DNA replication , inhibits PCNA - stimulated synthesis past model abasic template sites .
p21 , a specific inhibitor of PCNA - dependent DNA replication , inhibits PCNA - stimulated synthesis past model abasic template sites .
Consistent with previous observations , proliferating cell nuclear antigen ( PCNA ) promotes DNA synthesis by calf thymus DNA polymerase delta ( pol delta ) past several chemically defined template lesions including model abasic sites , 8-oxo - deoxyguanosine ( dG ) and aminofluorene - dG ( but not acetylaminofluorene - dG ) .
Consistent with previous observations , proliferating cell nuclear antigen ( PCNA ) promotes DNA synthesis by calf thymus DNA polymerase delta ( pol delta ) past several chemically defined template lesions including model abasic sites , 8-oxo - deoxyguanosine ( dG ) and aminofluorene - dG ( but not acetylaminofluorene - dG ) .
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