Proliferating cell nuclear antigen is required for DNA excision repair

@article{Shivji1992ProliferatingCN,
  title={Proliferating cell nuclear antigen is required for DNA excision repair},
  author={M. Shivji and M. Kenny and R. Wood},
  journal={Cell},
  year={1992},
  volume={69},
  pages={367-374}
}
Fractionation of extracts from human cell lines allows nucleotide excision repair of damaged DNA to be resolved into discrete incision and polymerization stages. Generation of incised intermediates depends on the XP-A protein, a polypeptide that recognizes sites of damaged DNA, and on the human single-stranded DNA-binding protein HSSB. The proliferating cell nuclear antigen (PCNA) is required for the DNA synthesis that converts the nicked intermediates to completed repair events. This need for… Expand
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