Proliferating cell nuclear antigen in the cytoplasm interacts with components of glycolysis and cancer.

@article{Naryzhny2010ProliferatingCN,
  title={Proliferating cell nuclear antigen in the cytoplasm interacts with components of glycolysis and cancer.},
  author={Stanislav N Naryzhny and Hoyun Lee},
  journal={FEBS letters},
  year={2010},
  volume={584 20},
  pages={4292-8}
}
Proliferating cell nuclear antigen (PCNA) is involved in a wide range of functions in the nucleus. However, a substantial amount of PCNA is also present in the cytoplasm, although their function is unknown. Here we show, through Far-Western blotting and mass spectrometry, that PCNA is associated with several cytoplasmic oncoproteins, including elongation factor, malate dehydrogenase, and peptidyl-prolyl isomerase. Surprisingly, PCNA is also associated with six glycolytic enzymes that are… CONTINUE READING
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