Proliferating cell nuclear antigen expression and argyrophilic nucleolar organizer regions as factors influencing prognosis of surgically treated lung cancer patients.

@article{Ishida1993ProliferatingCN,
  title={Proliferating cell nuclear antigen expression and argyrophilic nucleolar organizer regions as factors influencing prognosis of surgically treated lung cancer patients.},
  author={Toshikazu Ishida and Satoshi Kaneko and Kenji Akazawa and Masahiro Tateishi and Kenji Sugio and Keizo Sugimachi},
  journal={Cancer research},
  year={1993},
  volume={53 20},
  pages={5000-3}
}
Cell proliferation in 211 primary non-small cell lung carcinomas was assessed by using an immunostaining of proliferating cell nuclear antigen (PCNA) and a silver staining of argyrophilic nucleolar organizer region (Ag-NOR). More than 5% PCNA positive cells was designated PCNA(+), and less than 5% was PCNA(-). A mean number or more of the Ag-NOR was a high Ag-NOR count, and less than the mean number was a low Ag-NOR count. The proportion of the tumors with PCNA(+) and high Ag-NOR counts showed… CONTINUE READING

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