Proliferating cell nuclear antigen as a marker of cell kinetics in aberrant crypt foci, hyperplastic polyps, adenomas, and adenocarcinomas of the human colon.

@article{Shpitz1997ProliferatingCN,
  title={Proliferating cell nuclear antigen as a marker of cell kinetics in aberrant crypt foci, hyperplastic polyps, adenomas, and adenocarcinomas of the human colon.},
  author={Baruch Shpitz and Y. Bomstein and Yoseph A. Mekori and Rick Cohen and Zvi Kaufman and Mila Grankin and Joelle Bernheim},
  journal={American journal of surgery},
  year={1997},
  volume={174 4},
  pages={425-30}
}
BACKGROUND One of the first steps in multistage colonic carcinogenesis is increased cell proliferation and an upward shift of the proliferation zone of colonic crypts. In the present study, progression in cell kinetics was followed up at all sequential stages of colonic carcinogenesis, starting with aberrant crypt foci (ACF), the earliest putative preneoplastic lesions, hyperplastic and dysplastic polyps, and invasive carcinomas. MATERIALS AND METHODS Colonic tissue and tumor specimens were… CONTINUE READING
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