Proliferating cell nuclear antigen (PCNA) may function as a double homotrimer complex in the mammalian cell.

Abstract

The diverse function of proliferating cell nuclear antigen (PCNA) may be regulated by interactions with different protein partners. Interestingly, the binding sites for all known PCNA-associating proteins are on the outer surface or the C termini ("front") sides of the PCNA trimer. Using cell extracts and purified human PCNA protein, we show here that two… (More)

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