Proliferating cell nuclear antigen (PCNA): a new marker to study human colonic cell proliferation.

@article{Kubben1994ProliferatingCN,
  title={Proliferating cell nuclear antigen (PCNA): a new marker to study human colonic cell proliferation.},
  author={Frank J. G. M. Kubben and A Peeters-Haesevoets and Leopold G. J. Engels and C. G. M. I. Baeten and Bert Schutte and Jan Willem Arends and Reinhold W. Stockbr{\"u}gger and Geert H. Blijham},
  journal={Gut},
  year={1994},
  volume={35 4},
  pages={530-5}
}
Immunohistochemistry of the S phase related proliferating cell nuclear antigen (PCNA) was studied as an alternative to ex-vivo bromodeoxyuridine (BrdU) immunohistochemistry for assessment of human colonic cell proliferation. From 16 subjects without colonic disease biopsy specimens were collected from five different sites along the colorectum and processed for BrdU and PCNA immunohistochemistry. The mean proliferation index of PCNA was significantly higher at 133% of the value obtained with… CONTINUE READING

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