Proliferating brain cells are a target of neurotoxic CSF in systemic autoimmune disease.

Abstract

Brain atrophy, neurologic and psychiatric (NP) manifestations are common complications in the systemic autoimmune disease, lupus erythematosus (SLE). Here we show that the cerebrospinal fluid (CSF) from autoimmune MRL-lpr mice and a deceased NP-SLE patient reduce the viability of brain cells which proliferate in vitro. This detrimental effect was… (More)

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Cite this paper

@article{aki2005ProliferatingBC, title={Proliferating brain cells are a target of neurotoxic CSF in systemic autoimmune disease.}, author={Boris {\vS}aki{\'c} and David L Kirkham and David A Ballok and James Mwanjewe and Ian M. Fearon and Joseph Macri and Guanhua Yu and Michelle M. Sidor and Judah A. Denburg and Henry Szechtman and Jonathan Lau and Alexander K. Ball and Laurie C. Doering}, journal={Journal of neuroimmunology}, year={2005}, volume={169 1-2}, pages={68-85} }