Proleukemic RUNX1 and CBFbeta mutations in the pathogenesis of acute leukemia.

@article{Engel2010ProleukemicRA,
  title={Proleukemic RUNX1 and CBFbeta mutations in the pathogenesis of acute leukemia.},
  author={Michael Eugene Engel and Scott W. Hiebert},
  journal={Cancer treatment and research},
  year={2010},
  volume={145},
  pages={127-47}
}
The existence of non-random mutations in critical regulators of cell growth and differentiation is a recurring theme in cancer pathogenesis and provides the basis for our modern, molecular approach to the study and treatment of malignant diseases. Nowhere is this more true than in the study of leukemogenesis, where research has converged upon a critical group of genes involved in hematopoietic stem and progenitor cell self-renewal and fate specification. Prominent among these is the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-3 of 3 extracted citations

Similar Papers

Loading similar papers…