Prolactin signals via Stat5 and Oct-1 to the proximal cyclin D1 promoter.

@article{Brockman2005ProlactinSV,
  title={Prolactin signals via Stat5 and Oct-1 to the proximal cyclin D1 promoter.},
  author={Jennifer L Brockman and Linda A. Schuler},
  journal={Molecular and cellular endocrinology},
  year={2005},
  volume={239 1-2},
  pages={45-53}
}
Prolactin (PRL) modulates proliferation in the mammary gland and other tissues, in part through inducing transcription of cyclin D1, a key regulator of G(1) phase cell cycle progression. We showed previously that PRL, via Jak2, induces binding of Stat5 to a distal GAS site (GAS1) in the cyclin D1 promoter. However, full promoter activity requires additional regions, and in this paper we explored PRL-induced activity at sites other than GAS1. We defined a second PRL-responsive region spanning… CONTINUE READING

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