Prolactin-releasing peptide improved leptin hypothalamic signaling in obese mice.

  title={Prolactin-releasing peptide improved leptin hypothalamic signaling in obese mice.},
  author={Martina Holubov{\'a} and Lucie Hrub{\'a} and Barbora Nepra{\vs}ov{\'a} and Zuzana Majer{\vc}{\'i}kov{\'a} and Zdeňka Lacinov{\'a} and Jaroslav Kunes̆ and Lenka Malet{\'i}nsk{\'a} and Blanka Železn{\'a}},
  journal={Journal of molecular endocrinology},
  volume={60 2},
The situation following anti-obesity drug termination is rarely investigated, eventhough a decrease in body weight needs to be sustained. Therefore, this study examined the impact of twice-daily peripheral administration of 5 mg/kg [N-palm-γGlu-Lys11] prolactin-releasing peptide 31 (palm11-PrRP31) in mice with diet-induced obesity (DIO from consuming a high-fat diet) after 28 days of treatment (palm11-PrRP31 group) and after 14 days of peptide treatment followed by 14 days of discontinuation… CONTINUE READING