Prolactin releasing peptide (PrRP) stimulates luteinizing hormone (LH) and follicle stimulating hormone (FSH) via a hypothalamic mechanism in male rats.

@article{Seal2000ProlactinRP,
  title={Prolactin releasing peptide (PrRP) stimulates luteinizing hormone (LH) and follicle stimulating hormone (FSH) via a hypothalamic mechanism in male rats.},
  author={Leighton J. Seal and Caroline J. Small and Min Seon Kim and Sarah A Stanley and Saeid Taheri and Mohammad A. Ghatei and Stephen R. Bloom},
  journal={Endocrinology},
  year={2000},
  volume={141 5},
  pages={1909-12}
}
Prolactin releasing peptide (PrRP) was originally isolated as an endogenous hypothalamic ligand for the hGR3 orphan receptor. It has been shown to release prolactin from dispersed pituitaries harvested from lactating female rats and only at very high doses in cycling females. PrRP is reported to have no effect on prolactin production from dispersed pituitary cells harvested from males. The CNS distribution of this peptide suggested a role for PrRP in the control of the hypothalamo-pituitary… CONTINUE READING

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