Prolactin recruits STAT1, STAT3 and STAT5 independent of conserved receptor tyrosines TYR402, TYR479, TYR515 and TYR580.

@article{Dasilva1996ProlactinRS,
  title={Prolactin recruits STAT1, STAT3 and STAT5 independent of conserved receptor tyrosines TYR402, TYR479, TYR515 and TYR580.},
  author={Luis Dasilva and Hallgeir Rui and Rebecca A. Erwin and O. M. Zack Howard and Robert A. Kirken and Maria Grazia Malabarba and R H Hackett and Andrew C Larner and William L. Farrar},
  journal={Molecular and cellular endocrinology},
  year={1996},
  volume={117 2},
  pages={131-40}
}
The present study of prolactin (PRL) receptor-mediated recruitment of signal transducers and activators of transcription (STATs) demonstrates that PRL activates STAT3, in addition to STAT1 and STAT5 as previously reported, and that STAT1, STAT3 and STAT5 are mediators of PRL effects in cells whether of lymphoid, myeloid or mammary epithelial origin. Furthermore, receptor mutants M240 and T280 that do not mediate PRL-induced JAK2 activation and cell proliferation, are also unable to mediate STAT… CONTINUE READING

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