Prolactin promoter polymorphism (-1149 G/T) is associated with anti-DNA antibodies in Mexican patients with systemic lupus erythematosus.

@article{MontoyaDaz2011ProlactinPP,
  title={Prolactin promoter polymorphism (-1149 G/T) is associated with anti-DNA antibodies in Mexican patients with systemic lupus erythematosus.},
  author={Eduardo Montoya-D{\'i}az and Hernando Cervera-Castillo and Luis Ch{\'a}vez-S{\'a}nchez and Ma Victoria Legorreta-Haquet and Lourdes S{\'a}nchez-Gonz{\'a}lez and Karina A. Chavez-Rueda and Francisco A Blanco-Favela},
  journal={Immunological investigations},
  year={2011},
  volume={40 6},
  pages={614-26}
}
Prolactin (PRL) is a 23-kDa protein hormone that is synthesized mainly by the anterior pituitary gland. However, PRL can also be synthesized and secreted by extrapituitary tissues, particularly immune cells. A biallelic polymorphism (-1149 G/T) in the prolactin promoter has been shown to be functionally important, as modulation of prolactin expression has been associated with SLE in some populations. We have performed an association study using Mexican patients with SLE. We used qPCR to… CONTINUE READING

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