Prolactin mediates estradiol-induced inflammation in the lateral prostate of Wistar rats.

@article{Tangbanluekal1993ProlactinME,
  title={Prolactin mediates estradiol-induced inflammation in the lateral prostate of Wistar rats.},
  author={L Tangbanluekal and C L Robinette},
  journal={Endocrinology},
  year={1993},
  volume={132 6},
  pages={
          2407-16
        }
}
Inflammation was induced in the lateral prostate of castrated Wistar rats by exposure to a sc implant of estradiol-filled Silastic tubing, followed by the addition of a dihydrotestosterone implant to restore prostatic wet weight. The presence of inflammation was correlated with increased serum PRL, elevated pituitary weight, and a greater than 2-fold increase in the lateral prostate DNA concentration. The administration of bromocriptine (4 mg/kg.day) to these animals was effective in… CONTINUE READING

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