Prolactin involvement in breast cancer.

  title={Prolactin involvement in breast cancer.},
  author={Barbara K. Vonderhaar},
  journal={Endocrine-related cancer},
  volume={6 3},
Normal development and differentiation of the mammary gland are profoundly influenced by prolactin (PRL). In rodent mammary cancer PRL plays a well defined role, but its role, in human breast cancer has not been appreciated until recently. It is now clear that breast tissue, both normal and malignant, is a significant source of extrapituitary PRL. Thus an autocrine/paracrine role of PRL in human breast cancer may be invoked. Both PRL and PRL receptor mRNA are expressed in the vast majority of… CONTINUE READING

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