Prolactin induces Jak2 phosphorylation of RUSHY195

  title={Prolactin induces Jak2 phosphorylation of RUSHY195},
  author={Rebecca A. Helmer and Janet S. Dertien and Beverly S. Chilton},
  journal={Molecular and Cellular Endocrinology},
  • Rebecca A. Helmer, Janet S. Dertien, Beverly S. Chilton
  • Published 2011
  • Biology, Medicine
  • Molecular and Cellular Endocrinology
  • Jak2/RUSH-mediated prolactin signaling culminates in RUSH-1α-DNA-binding. Heretofore, Jak2-specific phosphorylation residues in RUSH were unknown. Genpathway's discovery approaches correlated RUSH-DNA binding (-126/-121) in uteroglobin's proximal promoter with recruitment of the transcriptional machinery. NetPhos 2.0 server found a single tyrosine phosphorylation site in RUSH's minimal DNA-binding domain. Y195 had identical context and prediction scores (0.52) for rabbit and human (HLTF… CONTINUE READING
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