Prolactin induces ERalpha-positive and ERalpha-negative mammary cancer in transgenic mice.

@article{RoseHellekant2003ProlactinIE,
  title={Prolactin induces ERalpha-positive and ERalpha-negative mammary cancer in transgenic mice.},
  author={Teresa A. Rose-Hellekant and Lisa M. Arendt and Matthew D Schroeder and Kennedy W. Gilchrist and Eric P. Sandgren and Linda A. Schuler},
  journal={Oncogene},
  year={2003},
  volume={22 30},
  pages={4664-74}
}
The role of prolactin in human breast cancer has been controversial. However, it is now apparent that human mammary epithelial cells can synthesize prolactin endogenously, permitting autocrine/paracrine actions within the mammary gland that are independent of pituitary prolactin. To model this local mammary production of prolactin (PRL), we have generated mice that overexpress prolactin within mammary epithelial cells under the control of a hormonally nonresponsive promoter, neu-related… CONTINUE READING