Prolactin decreases expression of Runx2, osteoprotegerin, and RANKL in primary osteoblasts derived from tibiae of adult female rats.

@article{Charoenphandhu2008ProlactinDE,
  title={Prolactin decreases expression of Runx2, osteoprotegerin, and RANKL in primary osteoblasts derived from tibiae of adult female rats.},
  author={Narattaphol Charoenphandhu and Jarinthorn Teerapornpuntakit and Methajit Methawasin and Kannikar Wongdee and Kanogwun Thongchote and Nateetip Krishnamra},
  journal={Canadian journal of physiology and pharmacology},
  year={2008},
  volume={86 5},
  pages={240-8}
}
Hyperprolactinemia caused by physiological or pathological conditions, such as those occurring during lactation and prolactinoma, respectively, results in progressive osteopenia. The underlying mechanisms, however, are controversial. Prolactin (PRL) may directly attenuate the functions of osteoblasts, since these bone cells express PRL receptors. The present study therefore aimed to investigate the effects of PRL on the expression of genes related to the osteoblast functions by using… CONTINUE READING

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