Prolactin as a mammalian mitogen and tumor promoter.

  title={Prolactin as a mammalian mitogen and tumor promoter.},
  author={Arthur R. Buckley and Charles W. Putnam and Diane Haddock Russell},
  journal={Advances in enzyme regulation},
Cellular proliferation and differentiation of the mammalian mammary gland requires a medley of hormones including the anterior pituitary hormone, PRL. Recent evidence extends the role of PRL as a mammalian mitogen to cells in several physiological systems not directly involved in reproductive functions, such as liver and lymphocytes. PRL administration induces biochemical markers expressed during the G1 phase of cell cycle and activates DNA synthesis in rat liver. Chronic PRL treatment causes… CONTINUE READING

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