Prolactin and lipopolysaccharide treatment increased apoptosis and atresia in rat ovarian follicles.

@article{Besnard2001ProlactinAL,
  title={Prolactin and lipopolysaccharide treatment increased apoptosis and atresia in rat ovarian follicles.},
  author={Nathalie Besnard and Eric A. Horne and Saffron Ann Whitehead},
  journal={Acta physiologica Scandinavica},
  year={2001},
  volume={172 1},
  pages={17-25}
}
Follicular atresia is associated with the presence of increased macrophages within the follicle. What is not known is whether, in the adult rat, macrophages are instrumental in inducing apoptosis and/or atresia or whether they are simply secondary to a hormonally mediated event. As prolactin is an immunoreactive hormone and stimulates the expression of monocyte chemoattractant, the present experiments compared the effects of prolactin treatment with that of an immune challenge with… CONTINUE READING