Prolactin, neurogenesis, and maternal behaviors

@article{Larsen2012ProlactinNA,
  title={Prolactin, neurogenesis, and maternal behaviors},
  author={Caroline M. Larsen and David R. Grattan},
  journal={Brain, Behavior, and Immunity},
  year={2012},
  volume={26},
  pages={201-209}
}
  • C. LarsenD. Grattan
  • Published 1 February 2012
  • Biology, Psychology, Medicine
  • Brain, Behavior, and Immunity

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Actions of Prolactin in the Brain: From Physiological Adaptations to Stress and Neurogenesis to Psychopathology

  • L. Torner
  • Biology, Psychology
    Front. Endocrinol.
  • 2016
The effects of PRL on neurogenesis and neuroprotection, the putative neuronal mechanisms underlying these effects, and their contribution to the onset of psychopathological states such as depression are discussed.

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It is demonstrated that prolactin-induced increase in generation of neural progenitors in the SVZ of the maternal brain during early pregnancy is required for normal expression of postpartum maternal behaviors.

Pregnancy-Stimulated Neurogenesis in the Adult Female Forebrain Mediated by Prolactin

It is shown that the production of neuronal progenitors is stimulated in the forebrain subventricular zone of female mice during pregnancy and that this effect is mediated by the hormone prolactin, implying that forebrain olfactory neurogenesis may contribute to adaptive behaviors in mating and pregnancy.

Exposure to female pheromones during pregnancy causes postpartum anxiety in mice.

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Findings indicate a stimulatory behavioral role for pituitary prolactin in the establishment of maternal care and suggest that exposure to Prolactin during pregnancy helps to stimulate the immediate onset of maternal behavior at parturition.

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...