Prolactin's role in the early stages of liver regeneration in rats.

  title={Prolactin's role in the early stages of liver regeneration in rats.},
  author={Isabel Mar{\'i}a Olazabal and Jaime A Mu{\~n}oz and Carmen Rodr{\'i}guez-Navas and Luis Alvarez and Emilio Delgado-Baeza and Josefa Predestinaci{\'o}n Garc{\'i}a-Ru{\'i}z},
  journal={Journal of cellular physiology},
  volume={219 3},
Liver regeneration after partial hepatectomy (PHx) is a complex process that is regulated by hemodynamic changes, the modulation of cytokines and growth factors, and the activation of immediate early transcription factors that lead to a round of hepatocyte mitosis. Among the factors involved, the pituitary hormone prolactin (PRL) has been shown to induce a hepatotrophic response after partial hepatectomy similar to that caused by phorbol esters; and in isolated hepatocytes PRL triggers a… CONTINUE READING


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