Prokineticin 2 Is a Hypothalamic Neuropeptide That Potently Inhibits Food Intake

  title={Prokineticin 2 Is a Hypothalamic Neuropeptide That Potently Inhibits Food Intake},
  author={James Gardiner and Attia Bataveljic and Neekhil A. Patel and Gavin A Bewick and Debabrata A. Roy and Daniel Campbell and Hannah C. Greenwood and Kevin Graeme Murphy and Saira Hameed and Preeti H. Jethwa and Francis J P Ebling and Steven P. Vickers and Sharon C. Cheetham and Mohammad A. Ghatei and Stephen R. Bloom and Waljit S. Dhillo},
OBJECTIVE Prokineticin 2 (PK2) is a hypothalamic neuropeptide expressed in central nervous system areas known to be involved in food intake. We therefore hypothesized that PK2 plays a role in energy homeostasis. RESEARCH DESIGN AND METHODS We investigated the effect of nutritional status on hypothalamic PK2 expression and effects of PK2 on the regulation of food intake by intracerebroventricular (ICV) injection of PK2 and anti-PK2 antibody. Subsequently, we investigated the potential… CONTINUE READING
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