Prokaryotic DNA Methyltransferases: The Structure and the Mechanism of Interaction with DNA

@article{Gromova2003ProkaryoticDM,
  title={Prokaryotic DNA Methyltransferases: The Structure and the Mechanism of Interaction with DNA},
  author={Elizaveta S. Gromova and Anton V Khoroshaev},
  journal={Molecular Biology},
  year={2003},
  volume={37},
  pages={260-272}
}
The review considers current views on the function of DNA methyltransferases (MTases) that belong to prokaryotic type II restriction–modification systems. A commonly accepted classification of MTases is described along with their primary and tertiary structures and molecular mechanisms of their specific interaction with DNA (including methylation). MTase inhibitors are also considered. Special emphasis is placed on the flipping of the target heterocyclic base out of the double helix and on the… CONTINUE READING

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