Projections from neocortex mediate top-down control of memory retrieval

@article{Rajasethupathy2015ProjectionsFN,
  title={Projections from neocortex mediate top-down control of memory retrieval},
  author={Priyamvada Rajasethupathy and Sethuraman Sankaran and James H. Marshel and Christina K Kim and Emily Ferenczi and Soo Yeun Lee and Andr{\'e} Berndt and Charu Ramakrishnan and Anna R Jaffe and Maisie Lo and C Liston and Karl Deisseroth},
  journal={Nature},
  year={2015},
  volume={526},
  pages={653-659}
}
Top-down prefrontal cortex inputs to the hippocampus have been hypothesized to be important in memory consolidation, retrieval, and the pathophysiology of major psychiatric diseases; however, no such direct projections have been identified and functionally described. Here we report the discovery of a monosynaptic prefrontal cortex (predominantly anterior cingulate) to hippocampus (CA3 to CA1 region) projection in mice, and find that optogenetic manipulation of this projection (here termed AC–CA… CONTINUE READING
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