Projection domains of MAP2 and tau determine spacings between microtubules in dendrites and axons

@article{Chen1992ProjectionDO,
  title={Projection domains of MAP2 and tau determine spacings between microtubules in dendrites and axons},
  author={J Chen and Yoshikatsu Kanai and Nicholas J. Cowan and Nobutaka Hirokawa},
  journal={Nature},
  year={1992},
  volume={360},
  pages={674-677}
}
NEURONS develop a highly polarized morphology consisting of dendrites and a long axon. Both axons and dendrites contain microtubules and microtubule-associated proteins (MAPs) with characteristic structures1. Among MAPs, MAP2 is specifically expressed in dendrites2 whereas MAP2C and tau are abundant in the axon2–5. But the influence of MAP2, MAP2C and tau on the organization of microtubule domains in dendrites versus axons is unknown. Both MAP2 and tau induce microtubule bundle formation in… CONTINUE READING

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 255 CITATIONS, ESTIMATED 81% COVERAGE

14-3-3/Tau Interaction and Tau Amyloidogenesis

  • Journal of Molecular Neuroscience
  • 2019
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Tau and axonopathy in neurodegenerative disorders

VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Neurofibrillary tangles mediated human neuronal tauopathies: insights from fly models

  • Journal of Genetics
  • 2018
VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

1993
2019

CITATION STATISTICS

  • 15 Highly Influenced Citations

  • Averaged 14 Citations per year from 2017 through 2019