• Biology, Medicine
• Published in Nature 1992
• DOI:10.1038/360674a0

Projection domains of MAP2 and tau determine spacings between microtubules in dendrites and axons

@article{Chen1992ProjectionDO,
  title={Projection domains of MAP2 and tau determine spacings between microtubules in dendrites and axons},
  author={J Chen and Yoshikatsu Kanai and Nicholas J. Cowan and Nobutaka Hirokawa},
  journal={Nature},
  year={1992},
  volume={360},
  pages={674-677}
}

• J Chen, Yoshikatsu Kanai, +1 author Nobutaka Hirokawa

NEURONS develop a highly polarized morphology consisting of dendrites and a long axon. Both axons and dendrites contain microtubules and microtubule-associated proteins (MAPs) with characteristic structures1. Among MAPs, MAP2 is specifically expressed in dendrites2 whereas MAP2C and tau are abundant in the axon2–5. But the influence of MAP2, MAP2C and tau on the organization of microtubule domains in dendrites versus axons is unknown. Both MAP2 and tau induce microtubule bundle formation in… CONTINUE READING

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