Projection Structure of a Member of the Amino Acid/Polyamine/Organocation Transporter Superfamily*

@article{Casagrande2008ProjectionSO,
  title={Projection Structure of a Member of the Amino Acid/Polyamine/Organocation Transporter Superfamily*},
  author={F. Casagrande and M. Ratera and A. Schenk and M. Chami and Eva Valencia and J. M. L{\'o}pez and D. Torrents and A. Engel and M. Palac{\'i}n and D. Fotiadis},
  journal={Journal of Biological Chemistry},
  year={2008},
  volume={283},
  pages={33240 - 33248}
}
The l-arginine/agmatine antiporter AdiC is a key component of the arginine-dependent extreme acid resistance system of Escherichia coli. Phylogenetic analysis indicated that AdiC belongs to the amino acid/polyamine/organocation (APC) transporter superfamily having sequence identities of 15–17% to eukaryotic and human APC transporters. For functional and structural characterization, we cloned, overexpressed, and purified wild-type AdiC and the point mutant AdiC-W293L, which is unable to bind and… Expand
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