Projection OCT fundus imaging for visualising outer retinal pathology in non-exudative age-related macular degeneration.

Abstract

AIMS To demonstrate ultrahigh-resolution, three-dimensional optical coherence tomography (3D-OCT) and projection OCT fundus imaging for enhanced visualisation of outer retinal pathology in non-exudative age-related macular degeneration (AMD). METHODS A high-speed, 3.5 mum resolution OCT prototype instrument was developed for the ophthalmic clinic. Eighty-three patients with non-exudative AMD were imaged. Projection OCT fundus images were generated from 3D-OCT data by selectively summing different retinal depth levels. Results were compared with standard ophthalmic examination, including fundus photography and fluorescein angiography, when indicated. RESULTS Projection OCT fundus imaging enhanced the visualisation of outer retinal pathology in non-exudative AMD. Different types of drusen exhibited distinct features in projection OCT images. Photoreceptor disruption was indicated by loss of the photoreceptor inner/outer segment (IS/OS) boundary and external limiting membrane (ELM). RPE atrophy can be assessed using choroid-level projection OCT images. CONCLUSIONS Projection OCT fundus imaging facilities rapid interpretation of large 3D-OCT data sets. Projection OCT enhances contrast and visualises outer retinal pathology not visible with standard fundus imaging or OCT fundus imaging. Projection OCT fundus images enable registration with standard ophthalmic diagnostics and cross-sectional OCT images. Outer retinal alterations can be assessed and drusen morphology, photoreceptor impairment and pigmentary abnormalities identified.

DOI: 10.1136/bjo.2007.136101
020406020102011201220132014201520162017
Citations per Year

100 Citations

Semantic Scholar estimates that this publication has 100 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Gorczyska2009ProjectionOF, title={Projection OCT fundus imaging for visualising outer retinal pathology in non-exudative age-related macular degeneration.}, author={Iwona Gorczyńska and Vivek J. Srinivasan and Laurel N. Vuong and Royce W. S. Chen and Julian J Liu and Elias Reichel and Maciej P. Wojtkowski and Joel S. Schuman and Jay S. Duker and James G. Fujimoto}, journal={The British journal of ophthalmology}, year={2009}, volume={93 5}, pages={603-9} }