Proinsulin levels and the proinsulin:c-peptide ratio complement autoantibody measurement for predicting type 1 diabetes

@article{Truyen2005ProinsulinLA,
  title={Proinsulin levels and the proinsulin:c-peptide ratio complement autoantibody measurement for predicting type 1 diabetes},
  author={I. Truyen and P. Pauw and P. N. J{\o}rgensen and C. Schravendijk and O. Ubani and K. Decochez and E. Vandemeulebroucke and I. Weets and R. Mao and D. G. Pipeleers and F. K. Gorus and The Belgian Diabetes Registry},
  journal={Diabetologia},
  year={2005},
  volume={48},
  pages={2322-2329}
}
Aims/hypothesisWe investigated whether random proinsulin levels and proinsulin:C-peptide ratio (PI:C) complement immune and genetic markers for identifying relatives at high risk of type 1 diabetes.Materials and methodsDuring an initial sampling, random glycaemia, proinsulin, PI:C and HLA DQ genotype were determined in 561 non-diabetic first-degree relatives who had been positive for islet autoantibodies on one or more occasions and in 561 age- and sex-matched persistently antibody-negative… CONTINUE READING
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