Proinsulin and insulin concentrations in relation to carotid wall thickness: Insulin Resistance Atherosclerosis Study.

@article{Haffner1998ProinsulinAI,
  title={Proinsulin and insulin concentrations in relation to carotid wall thickness: Insulin Resistance Atherosclerosis Study.},
  author={Steven M. Haffner and R. D'agostino and Leena Mykk{\"a}nen and Charles Nicholas Hales and Peter J. Savage and Richard N Bergman and Daniel O'Leary and Marian Rewers and Joseph Selby and Russell Tracy and Mohammed F. Saad},
  journal={Stroke},
  year={1998},
  volume={29 8},
  pages={
          1498-503
        }
}
BACKGROUND AND PURPOSE Insulin resistance and hyperinsulinemia have been associated with atherosclerosis. Recent attention has focused on the possible role of proinsulin because most radioimmunoassays for insulin cross-react with proinsulin. Therefore, it is not known which of the two, insulin per se or proinsulin, is more strongly related to atherosclerosis. METHODS We examined the relation between fasting proinsulin, fasting split proinsulin, fasting and 2-hour insulin (after oral glucose… CONTINUE READING

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