Proinsulin and acute insulin response independently predict Type 2 diabetes mellitus in men—report from 27 years of follow-up study

@article{Zethelius2003ProinsulinAA,
  title={Proinsulin and acute insulin response independently predict Type 2 diabetes mellitus in men—report from 27 years of follow-up study},
  author={Bj{\"o}rn Zethelius and L Byberg and Charles Nicholas Hales and Hans 0. Lithell and Christian Berne},
  journal={Diabetologia},
  year={2003},
  volume={46},
  pages={20-26}
}
Aims/hypothesis. Defects in insulin secretion and insulin action, resulting in compensatory hyperinsulinaemia, are the major abnormalities in the development of Type 2 diabetes mellitus (Type 2 diabetes). The most frequently used conventional immunoreactive assays for insulin cross-react with proinsulin. In short-term studies (<5 years), proinsulin predicts the development of Type 2 diabetes. We studied, with a 27-year follow-up, the longitudinal relationships between intact proinsulin, 32–33… CONTINUE READING