Proinsulin C-peptide inhibits lipolysis in diabetic rat adipose tissue through phosphodiestrase-3B enzyme.

  title={Proinsulin C-peptide inhibits lipolysis in diabetic rat adipose tissue through phosphodiestrase-3B enzyme.},
  author={Ahmad Ghorbani and Gholamhossein Ranjbar Omrani and Mousa-Al-Reza Hadjzadeh and Masoumeh Varedi},
  journal={Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme},
  volume={45 3},
  • A. GhorbaniG. Omrani M. Varedi
  • Published 18 September 2012
  • Biology
  • Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
We have previously reported that C-peptide modulates insulin-mediated inhibition of lipolysis and glucose consumption but has no significant effects per se on adipose tissue of normal rats. It has been repeatedly observed that certain actions of C-peptide are restricted to the diabetic states. In the present study, therefore, we examined whether C-peptide alters lipolysis in adipose tissue of diabetic rats. Rats were rendered diabetic by streptozotocin and divided into 2 groups; insulin treated… 

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