Proinflammatory tachykinins that signal through the neurokinin 1 receptor promote survival of dendritic cells and potent cellular immunity.

@article{Janelsins2009ProinflammatoryTT,
  title={Proinflammatory tachykinins that signal through the neurokinin 1 receptor promote survival of dendritic cells and potent cellular immunity.},
  author={Brian M. Janelsins and Alicia Mathers and Olga A. Tkacheva and Geza Erdos and William J. Shufesky and Adrian E Morelli and Adriana T. Larregina},
  journal={Blood},
  year={2009},
  volume={113 13},
  pages={3017-26}
}
Dendritic cells (DCs) are the preferred targets for immunotherapy protocols focused on stimulation of cellular immune responses. However, regardless of initial promising results, ex vivo generated DCs do not always promote immune-stimulatory responses. The outcome of DC-dependent immunity is regulated by proinflammatory cytokines and neuropeptides. Proinflammatory neuropeptides of the tachykinin family, including substance P (SP) and hemokinin-1 (HK-1), bind the neurokinin 1 receptor (NK1R) and… CONTINUE READING

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