Proinflammatory signalling stimulated by the type III translocation factor YopB is counteracted by multiple effectors in epithelial cells infected with Yersinia pseudotuberculosis.

@article{Viboud2003ProinflammatorySS,
  title={Proinflammatory signalling stimulated by the type III translocation factor YopB is counteracted by multiple effectors in epithelial cells infected with Yersinia pseudotuberculosis.},
  author={Gloria I. Viboud and Stephane Shu Kin So and Michelle B. Ryndak and James B Bliska},
  journal={Molecular microbiology},
  year={2003},
  volume={47 5},
  pages={1305-15}
}
Type III secretion systems are used by several pathogens to translocate effector proteins into host cells. Yersinia pseudotuberculosis delivers several Yop effectors (e.g. YopH, YopE and YopJ) to counteract signalling responses during infection. YopB, YopD and LcrV are components of the translocation machinery. Here, we demonstrate that a type III translocation protein stimulates proinflammatory signalling in host cells, and that multiple effector Yops counteract this response. To examine… CONTINUE READING

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