Proinflammatory role of amphiregulin, an epidermal growth factor family member whose expression is augmented in rheumatoid arthritis patients

@article{Yamane2007ProinflammatoryRO,
  title={Proinflammatory role of amphiregulin, an epidermal growth factor family member whose expression is augmented in rheumatoid arthritis patients},
  author={Shoji Yamane and Satoru Ishida and Yukie Hanamoto and Ken-ichi Kumagai and Riako Masuda and Konagi Tanaka and Noriyuki Shiobara and Noriko Yamane and Toshihito Mori and Takuo Juji and Naoshi Fukui and Tsunetoshi Itoh and Takahiro Ochi and Ryuji Suzuki},
  journal={Journal of Inflammation (London, England)},
  year={2007},
  volume={5},
  pages={5 - 5}
}
The epidermal growth factor (EGF) and EGF receptor (EGFR) families play important roles in the hyperplastic growth of several tissues as well as tumor growth. Since synovial hyperplasia in rheumatoid arthritis (RA) resembles a tumor, involvement of the EGF/EGFR families in RA pathology has been implied. Although several reports have suggested that ErbB2 is the most important member of the EGFR family for the synovitis in RA, it remains unclear which members of the EGF family are involved. To… CONTINUE READING

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Production of interleukin-6 and interleukin-8 by nurse-like cells from rheumatoid arthriPage 12 of 13 (page number not for citation purposes) Journal of Inflammation

  • K Tanaka, T Mori, +8 authors T Ochi
  • Mod Rheumatol
  • 2005
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