Proinflammatory response of alveolar epithelial cells is enhanced by alveolar macrophage-produced TNF-alpha during pulmonary ischemia-reperfusion injury.

@article{Sharma2007ProinflammatoryRO,
  title={Proinflammatory response of alveolar epithelial cells is enhanced by alveolar macrophage-produced TNF-alpha during pulmonary ischemia-reperfusion injury.},
  author={Ashish K Sharma and L Garc{\'i}a- Fern{\'a}ndez and Alaa S. Awad and Irving L. Kron and Victor E Laubach},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2007},
  volume={293 1},
  pages={L105-13}
}
Pulmonary ischemia-reperfusion (IR) injury entails acute activation of alveolar macrophages followed by neutrophil sequestration. Although proinflammatory cytokines and chemokines such as TNF-alpha and monocyte chemoattractant protein-1 (MCP-1) from macrophages are known to modulate acute IR injury, the contribution of alveolar epithelial cells to IR injury and their intercellular interactions with other cell types such as alveolar macrophages and neutrophils remain unclear. In this study, we… CONTINUE READING