Proinflammatory mediators upregulate snail in head and neck squamous cell carcinoma.

  title={Proinflammatory mediators upregulate snail in head and neck squamous cell carcinoma.},
  author={Maie A R St John and Mariam Dohadwala and Jie Luo and Guanyu Wang and Gina Lee and Hubert B. Shih and Eileen L. Heinrich and Kostantyn Krysan and Tonya C. Walser and Saswati Hazra and Li Zhu and Chi Ren Lai and Elliot Abemayor and Michael C. Fishbein and David A. Elashoff and Sherven P Sharma and Steven Dubinett},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={15 19},
PURPOSE Inflammatory cytokines have been implicated in the progression of head and neck squamous cell carcinoma (HNSCC). Herein we investigate the mechanisms by which interleukin-1beta (IL-1beta) might contribute to Epithelial-Mesenchymal Transition (EMT) in HNSCC. EXPERIMENTAL DESIGN We evaluated the effect of IL-1beta on the molecular events of EMT in surgical specimens and HNSCC cell lines. We examined the correlation with tumor histologic features, and a SCID xenograft model was used to… CONTINUE READING


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